Saturday, February 17, 2024

Collagen Supplements And Breast Cancer

Answer: Use Of Supplements And Collagen After Breast Augmentation

Understanding the Role of Collagen in Breast Cancer

Thank you for the question. Despite your interest in the use of supplements, I do not think that there is any evidence that supplements or of collagen help or hurt after breast augmentation surgery. On the other hand, I think that you could potentially waste a lot of time, energy, and resources if you were to believe everything you read and/or hear. As far as resuming supplements and/or medications after surgery, patients should follow their plastic surgeons recommendations ultimately he said/she knows exactly how you are progressing and is responsible for your care. Best wishes.

Taking Collagen After Breast Cancer

Bovine collagen comes from cows preferably grass-fed cows.

There are 3 various sorts of collagen: collagen I, II, as well as III. Each type of collagen sustains various parts of the body. In bovine collagen made from hide, youll normally locate types I and also III which operate in similar ways to support skin, bones, muscular tissues, tendons, as well as intestine health and wellness.

If you acquire a bovine collagen supplement made from cartilage, connective tissues, or bones, this supplement must additionally have collagen kind II which assists support joint health in particular.

Are Collagen Supplements Safe

Unlike drugs, the FDA doesnt approve dietary supplements to prevent or treat medical conditions. And supplement manufacturers do not need to prove a new product is safe before selling it. However, the FDA does monitor serious adverse impacts of supplements after they hit the market.

The most significant concern with collagen supplements comes from how they are made. Unless labeled as vegan or plant-derived, most collagen supplements come from ground up connective tissue of fish, chicken, or pork. The main concern with collagen supplements derived from animals is that they may contain dangerous heavy metals or other contaminants.

A review of 11 collagen supplements by ConsumerLab found cadmium, a toxic heavy metal, in one brand. To ensure the purity of supplements you take, Consumer Reports recommends looking for products certified by ConsumerLab.com, NSF International, or U.S. Pharmacopeia .

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How To Care For Your Scars And Minimize Their Appearance

Long before the incisions of a breast reduction turn into scars, you should follow your surgeons instructions for post-care.

Make sure you keep wearing chest bandages and your surgical bra for the first few days after surgery. Youll likely see your surgeon for a follow-up after this time. Theyll advise you on how to take care of your skin as it heals.

Once the incisions close, there are scar-minimizing techniques you may consider trying during the healing process . Your doctor may recommend more than one approach.

Cell Lines And Culture Conditions

Elemis to donate £25,000 to Breast Cancer Care

MDA-MB-231 were maintained in DMEM/F12 with 10% FBS and 1% Pen/Strep. BT549 cells were maintained in RPMI-1640 with 10% FBS and 1% Pen/Strep. MCF-10A cells were kind gifts from Michael W. Kilgore, University of Kentucky, Lexington, KY. MCF10A cells were cultured as previously described . Hs-578 T cells were kept as previously described . S1 and T42 cells are kind gifts from Dr. Mina J Bissell, and they were cultured as previously described . All the cells were tested for mycoplasma contamination every two months.

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Phytoestrogens And Soy: The Debate

Phytoestrogens are compounds that have a mild estrogenic effect and are found in whole grains, nuts and seeds, and many other botanicals, fruits and vegetables. These foods are associated with a reduced risk of breast cancer as well as reduced cancer reoccurrence.

The controversy becomes heated in the debate over soy-containing foods. This issue is complex, with some studies showing that eating soy early in life can reduce breast cancer risk. On the other hand, the consumption of concentrated soy extracts showed increased proliferation of breast cancer cells. Finally, other studies show a protective or neutral effect from whole soy foods.

My recommendation for soy is to eat whole soy foods in moderation no more than several servings per week, preferably fermented soy foods such as miso or tempeh. Avoid soy protein isolates and supplements containing concentrated soy isoflavones.

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Scaffold Molding And Cell Seeding

Eight hundred microgram of collagen/well of a Costar 96 plate was used to mold scaffolds. Collagen samples were lyophilized after collagen deposition on the plates. Samples were frozen at 20°C and then lyophilization was achieved using a Scanvac Coolsafe 55-9 freeze drier . After, scaffold were crosslinked using 1-ethyl- carbodiimide hydrochloride in 80% ethanol at 1% w/v for 90 min. Cross-linked scaffolds were rinsed in deionized water three times and left in 1% glycine overnight, at room temperature, to quench the reaction. Finally, constructs were lyophilized again to get all the residual liquid out and preserve their cylindrical shape.

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Uncovering Collagens Role In Breast Cancer Metastasis

The study by the Garvan researchers was aimed at better understanding the role of the 300 to 400 molecules typically present in the extracellular matrix, a meshwork that provides support to all tissues in the body. The investigators looked to better understand how the tumor matrix changes over time and soon focused on collagen XII, one of 28 collagen types found in the body. Collagen XII helps to organize other collagens and plays an important role in the 3D structure of the extracellular matrix.

Using an array of tumor tissue types from early preclinical mouse models through to late-stage cancer, the Garvan team was able to demonstrate how the molecular makeup of the extracellular matrix changed over the development of tumors and catalogued these findings. They found that as the tumors developed, among the changes of many other matrix molecules, the level of collagen XII was also increased.

To determine the clinical relevance of collagen XII in breast cancer patients, collagen XII expression was analyzed in RNAseq data from the Cancer Genome Atlas breast cancer cohort, which confirmed significant upregulation of collagen XII across all primary breast tumor types, including TNBC, relative to non-tumor tissue.

Future studies to the role of collagen XII will seeks to include more humor tumor samples, while also exploring potential therapeutic pathways.

Collagen Xiii Expression Is Increased During Breast Cancer Development

Patricia Keely on Collagen’s Role in Breast Cancer

To determine whether collagen XIII expression is induced during breast cancer development, we analyzed collagen XIII protein levels in a panel of non-malignant and malignant mammary epithelial cells. Triple negative breast cancer cell line MDA-MB-231, Hs578T, BT549, and T42 expressed higher levels of collagen XIII protein than luminal type breast cancer cell lines and non-malignant mammary epithelial cell lines . By analyzing TCGA and Finak datasets , we found that collagen XIII mRNA levels were significantly increased in human breast cancer tissue compared to normal mammary gland tissue . Collagen XIII expression in ER negative breast cancer was much higher than the expression in ER positive breast cancer . Consistence with cancer cell line data, we also found that triple negative breast cancer tissue had higher level of collagen XIII expression compared with other subtypes .

Fig. 1

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Ecm Remodeling During Cancer Invasion

During cancer invasion, tumor stroma undergoes constant architectural changes, characterized by collagens degrading, re-depositing, cross-linking and stiffening in terms of ECM remodeling, and immune infiltration and re-differentiation of monocytes at the invasive front in terms of cellular changes.

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Could Dietary Supplements Boost Breast Cancer Risk

Some antioxidant supplements may offset the anticancer effects of chemotherapy.

Certain dietary supplements may increase breast cancer recurrence risk and hasten death, according to a study published in the Journal of Clinical Oncology. Multivitamins, however, appear to be safe.

While the link between supplement intake and breast cancer risk remains tenuous, some previous research has found that certain supplements may reduce the effectiveness of chemotherapy treatments. Antioxidants in particular break down the cancer-killing free radicals that chemotherapy produces, according to the American Institute for Cancer Research .

The studys researchers recruited 1,134 people receiving chemotherapy for breast cancer who had a high risk of recurrence and followed them for 15 years or until they died of the disease. The participants completed a questionnaire about their supplement intake twice: once upon enrollment in the study and again six months after the conclusion of treatment. In total, 18% reported taking an antioxidant during treatment and 44% reported taking at least one multivitamin during treatment.

Lead study author Christine B. Ambrosone, PhD, the chair of the Department of Cancer Prevention and Control at Roswell Park Comprehensive Cancer Center, offered a possible explanation for these results. When you just pluck out specific vitamins and minerals from foods, you are losing all the effects that are probably there when using these nutrients from food, she said.

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Are There Any Vitamins Or Supplements That You Would Strongly Suggest A Person With Breast Cancer Doesnt Take

I advise against taking dietary supplements that may have strong effects on levels in the body. This includes DHEA, red clover and licorice. Any that is labeled to naturally support a womans hormones or as a natural option are also things that I advise against using for anyone with a history of breast cancer.

Physiological And Physicochemical Properties Of Collagen

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Collagen is a type of right-handed helix glycoprotein that contains three homologous or nonhomologous left-handed helix chains. These chain amino acid sequences are characterized by glycineXY repeats with or without interruptions, with X and Y most likely being proline or hydroxyproline, and the hydroxyproline content of collagen contributes to its thermal stability .

Collagen is released into the extracellular matrix to form a fibril supramolecular assembly that may start in Golgi-to-membrane carriers after procollagen excision or be localized at the plasma membrane of fibroblasts. The stability of collagen assembly is influenced by intramolecular and intermolecular linkages, particularly covalent linkages, chiefly including lysyl oxidase crosslinks , glycosylation crosslinks , and transglutaminase crosslinks , which vary across collagen types.

Different collagens in the ECM are finally degraded by various matrix metalloproteinases belonging to the zinc-dependent endopeptidase family, by proline oxidase, or by sheddases that release the soluble ectodomain of membrane collagens .

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Can Supplements Help With Cancer

Adding vitamins, minerals and other natural remedies to your daily regimen can boost some peoples immune system, energy level and overall health. But if youve been diagnosed with cancer, and especially if you are undergoing treatment, certain supplements may actually harm you. Some may even counteract anti-cancer treatments like chemotherapy. Thats why it is essential that patients always consult with their oncologists before taking any supplements .

If Cancer Comes Back Or Has Spread

AIs, tamoxifen, and fulvestrant can be used to treat more advanced hormone-positive breast cancers, especially in post-menopausal women. They are often continued for as long as they are helpful. Pre-menopausal women might be offered tamoxifen alone or an AI in combination with an LHRH agonist for advanced disease.

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Reversible Changes Of Bm: Opening The Door For Non

At initial phase of tumor invasion, BM is breached as tumor cells invade into interstitial tissue and colonize distant organs. Although proteolysis-dependent collagen degradation is important for this process, there is much evidence showing that proteolysis is dispensable in the BM transmigration events .

Thus, collagen increase and decrease are both involved in tumor progression, and these two processes are coordinated reciprocally to promote tumor invasion and metastasis. First, LOX mediated collagen cross-linking can recruit some stromal cells to adhere and secrete more MMPs. Then, MMPs can degrade collagen to expose active sites to generating a pro-tumorigenic microenvironment to facilitate tumor progression. Although direct mechanisms have not been elucidated, MMPs are associated with LOX expression in breast cancer . LOX mediated collagen cross-linking seems to function in synergy with MMPs, which may lead to ECM remodeling favoring tumor progression.

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Collagen plays an important part in breast cancer metastasis: Study

This advice is widely repeated on many reputable cancer websites. The American Cancer Society states that So far, no dietary supplements have been shown to clearly help lower the risk of breast cancer progressing or coming back, along with the advice to patients to speak to a member of their healthcare team if a patient is considering taking supplements.

I was never going to take anything that might reduce my chances of survival. However Im sure some cancer patients are desperate for the promise of a cure and will ignore this advice whilst they take every supplement recommended to them, said ORiordan.

Vitamin supplements, particularly multivitamins have had a rough couple of years with several studies questioning whether they have any positive effects on health at all. This analysis of almost half a million people by Johns Hopkins researchers entitled Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements, found that multivitamin use did not decrease the risk of cancer, heart disease or help with cognitive decline. Experts recommend that the best way to ensure an adequate intake of vitamins and minerals is to eat a healthy, balanced diet.

So if many popular nutritional supplements are of questionable benefit for healthy people and increasingly not often recommended by healthcare professionals, where are people with cancer getting the message that they should take these?

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Purewild Co Launches Funding Platform For Collagen Supplements For Women With Breast Cancer

PureWild Co, the Ojai, California based company that makes clean marine collagen drinks and collagen infused wines, has finalized a collagen supplement formula created specifically for women with breast cancer, autoimmune diseases and osteoporosis.

Founder Cindy Convery worked with oncologists and nutritionists to create a daily supplement that blends certified nonGMO wild marine collagen with super vitamin C to maximize absorption for bone, skin and hair health. Breast cancer and autoimmune disease patients suffer from weakened skin and hair, along with potential bone loss due to the treatments and medications for those diseases. PureWilds supplements are the first to market that are formulated specifically for these consumers.

PureWild Co. has partnered with the Susan G. Komen Foundation and the National Breast Cancer Foundation to increase awareness for the supplements. As part of PureWilds charity program the company will donate a monthly supplement subscription to a woman in need for every three subscriptions sold. Supplements will be available for sale directly through the website and launch this October as part of Breast Cancer Awareness month.

PureWild Co.s funding platform can be found here:

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What Are The Best Moisturizers For Your Skin While Youre Being Treated With Chemotherapy

Use only moisturizers with rich oils and water-binding ingredients that soak deeply into your skin. This keeps you from feeling greasy after applying them, and it keeps them from soiling your clothes.

Remember, moisturizers only work if they are applied right after youve had your skin in water. This is because they dont moisturize they trap the water that you just soaked up into your skin while your skin is wet. apply your moisturizer within the Magic 3 Minutes after toweling dry. Dermatologist Dr. Cynthia Bailey

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Hollings Researcher Receives Award To Study Collagen Regulation In Breast Cancer Health Disparities

An MUSC Hollings Cancer Center researcher received a $3 million grant from the National Cancer Institute to study how patterns of collagens can serve as biomarkers of breast cancer risk and potentially reveal clues to what might be driving health disparities.

Peggi Angel, Ph.D., is applying innovative proteomic profiling techniques to decipher the biological foundations of lethal breast cancers that impact African American women more than any other race or ethnicity. Alarmingly, African American women are more than twice as likely as white women of European descent to be diagnosed with an aggressive form of breast cancer characterized by triple negative tumor subtypes that are more likely to metastasize, seeding tumor growth in other areas of their bodies and complicating the treatments they receive.

Angel believes that collagen, one of the most abundant types of protein classes in the human body, might play a significant role in driving these disparities in breast cancer severity. Problems with collagen processing are a primary feature of triple negative breast cancer tumors, and these issues appear to be particularly exacerbated in breast tissues of African American women as compared to Caucasians.

Hydroxyproline modification of collagen is critical to tissue stability. The collagen matrix that forms the structural basis of skin, bones and other organs is a highly dynamic environment that is constantly being reorganized and renewed, she explained.

How Can You Reduce The Risk Of Breast Cancer Recurrence

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To help yourself better cope with the side effects of breast cancer treatment and to reduce your chances of breast cancer recurrence, try incorporating these healthy tips: Take care of yourself emotionally. Take care of yourself physically. Eat healthy. Reduce stress. Limit alcohol. Exercise regularly.More items

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Taking Supplements During Breast Cancer Treatment Increases Risk Of Death And Relapse What Does This Mean For Patients

A new study found that people with breast cancer who take supplements have a poorer survival rate … and a larger chance of relapse than those who don’t.

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Last month a study of over 1,000 people with breast cancer found some worrying evidence that certain nutritional supplements could reduce the chance of survival from the disease and increase the chance that the cancer would recur after treatment. The main findings were:

  • Patients who reported taking any antioxidant – vitamins A, C, E and carotenoids and Coenyzme Q10 – were 41 percent more likely to have their breast cancer return when they took the supplements both before and during chemotherapy treatment
  • Patients had a similar, but weaker, increased risk of death when taking those antioxidants
  • Patients taking vitamin B12, iron, and omega-3 fatty acid supplements were at significantly greater risk of breast cancer recurrence and death
  • Patients taking multivitamins showed no signs of poorer or better outcomes after chemotherapy

The research was published in the Journal of Clinical Oncology and led by scientists at the SWOG cancer research institute.

Patients using any antioxidant before and during chemotherapy had an increased risk of their breast cancer returning and, to a lesser degree, had an increased risk of death. Vitamin B12, iron, and omega-3 fatty acid use was also associated with poorer outcomes, said Christine B. Ambrosone, PhD, of Roswell Park Comprehensive Cancer Center and leader of the study.

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