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Lupron Injection For Prostate Cancer

Drugs Used With Lupron Depot For Palliative Treatment Of Advanced Prostate Cancer

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When treating advanced prostate cancer, Lupron Depot is often used with other drugs to reduce the risk of a tumor flare. These drugs are called anti-androgen medications.

Lupron Depot works by stopping your body from making certain hormones, like testosterone. When you first start taking Lupron Depot, your body may respond by producing too much testosterone. This can have negative side effects such as bone pain and paralysis. Lowering the risk of a testosterone flare can help lower your risk for these side effects.

Anti-androgen medications can be given with Lupron Depot or before you start Lupron Depot. Examples of these medications include bicalutamide , nilutamide , and flutamide .

Here are answers to some frequently asked questions about Lupron Depot.

Drugs That Stop Androgens From Working

Anti-androgens

For most prostate cancer cells to grow, androgens have to attach to a protein in the prostate cancer cell called an androgen receptor. Anti-androgens are drugs that also connect to these receptors, keeping the androgens from causing tumor growth. Anti-androgens are also sometimes called androgen receptor antagonists.

Drugs of this type include:

  • Flutamide

They are taken daily as pills.

In the United States, anti-androgens are not often used by themselves:

  • An anti-androgen may be added to treatment if orchiectomy or an LHRH agonist or antagonist is no longer working by itself.
  • An anti-androgen is also sometimes given for a few weeks when an LHRH agonist is first started. This can help prevent a tumor flare.
  • An anti-androgen can also be combined with orchiectomy or an LHRH agonist as first-line hormone therapy. This is called combined androgen blockade . There is still some debate as to whether CAB is more effective in this setting than using orchiectomy or an LHRH agonist alone. If there is a benefit, it appears to be small.
  • In some men, if an anti-androgen is no longer working, simply stopping the anti-androgen can cause the cancer to stop growing for a short time. This is called the anti-androgen withdrawal effect, although it is not clear why it happens.

Newer anti-androgens

Enzalutamide , apalutamide and darolutamide are newer types of anti-androgens.

These drugs are taken as pills each day.

Less Common But Serious Risks

Less common but more serious side effects can accompany leuprolide including Tumor Flare Phenomenon, increased blood sugar, and injection site reaction. Additionally, leuprolide may increase an individuals risk of developing diabetes and cardiovascular complications, including an increased risk of heart attack, stroke, and sudden cardiac death. Individuals taking leuprolide should also be monitored for convulsions. Leuprolide may also cause a decrease in bone mineral density, leading to osteoporosis .

Tumor Flare Phenomenon is possible while taking leuprolide, in which tumor growth is accelerated for a short time before it is halted. Alert your provider immediately if you notice any serious signs of Tumor Flare Phenomenon including:

  • Weakness or loss of feeling in legs
  • Have trouble urinating or are unable to urinate
  • Experience new or worsening bone pain

You should also contact your provider if you notice any signs of an allergic reaction to the medication, including chest pain or difficulty breathing.

Before starting leuprolide talk to your provider if you:

  • Have any heart or blood vessel conditions such as irregular heart beat
  • Have a history of seizures or epilepsy
  • Are taking any medications for any cardiovascular conditions
  • Have high blood pressure
  • Have a condition that affects the strength of your bones
  • Are taking any other medications , vitamins, or herbal supplements

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How Should I Use Lupron Depot

Use Lupron Depot exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Different brands or strengths of leuprolide are used to treat different conditions. It is very important that you receive exactly the brand and strength your doctor has prescribed. Always check your medication to make sure you have received the correct brand and type prescribed by your doctor.

Lupron Depot is injected under the skin or into a muscle, once every month or once every 3 to 6 months. A healthcare provider can teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use Lupron Depot if you don’t understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Your symptoms may become temporarily worse as your hormones adjust to leuprolide.

Keep using the medicine as directed, and tell your doctor if your condition is still worse after 2 months of using Lupron Depot.

You may need frequent medical tests while using Lupron Depot.

Store Lupron Depot in the original carton at room temperature, away from moisture and heat. Protect from light.

Use a needle and syringe only once and then place them in a puncture-proof “sharps” container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Will I Need To Use This Drug Long Term

3.75mg Lupron Depot Leuprolide injection, Rs 3251.41 /vial Novacare ...

How long you use Lupron Depot will depend on the condition its being used to treat.

If youre taking Lupron Depot for advanced prostate cancer, youll likely use it long term to ease your prostate cancer symptoms and to stop your prostate cancer tumor from growing.

Lupron Depot is not typically used long term for endometriosis, uterine fibroids, or central precocious puberty. How long its used for these conditions depends on how well it relieves symptoms and how severe the condition is. Your doctor can tell you more.

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Alternatives To Lupron Depot

Other drugs are available that can treat your condition. Some may be a better fit for you than others. If youre interested in finding an alternative to Lupron Depot, talk with your doctor. They can tell you about other medications that may work well for you.

Note: Some of the drugs listed here are used off-label to treat these specific conditions. Off-label use is when a drug thats approved to treat one condition is prescribed to treat a different condition.

Will Lupron Depot Affect My Ability To Get Pregnant Or Get My Partner Pregnant

Lupron Depot may temporarily decrease fertility in adults. However, once Lupron Depot treatment ends, this decrease in fertility typically goes away after a period of time. And use of Lupron Depot-Ped in children isnt known to affect fertility long term.

In some cases, Lupron Depot is prescribed off-label as a part of an infertility treatment called the luteal Lupron protocol.

For more details about Lupron Depot and fertility, see the Lupron Depot and pregnancy section below.

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Lupron Depot For Endometriosis

Lupron Depot is FDA-approved to treat endometriosis in adults. It can help relieve pain associated with endometriosis. It can also reduce the size of lesions .

With endometriosis, the lining normally found inside the uterus begins to grow outside the uterus. This may occur in the ovaries, fallopian tubes, or other areas. These lesions can bleed and break down, resulting in pain and scar tissue. The lesions grow with the help of a hormone called estrogen thats naturally produced in the body.

Lupron Depot contains the drug leuprolide acetate, which belongs to a class of drugs called gonadotropin releasing hormone agonists. It works by blocking your body from creating certain hormones, like estrogen. This can help stop lesions from growing.

One of the possible side effects of Lupron Depot is a loss of bone density. Norethindrone acetate is a drug often given with Lupron Depot to help prevent bone density loss.

Effectiveness for endometriosis

In 6-month clinical studies, females* with endometriosis received either a 3.75-mg injection of Lupron Depot each month or an 800-mg tablet of danazol every day. At the end of the studies, both therapies were found to be effective in relieving pelvic pain and tenderness, painful periods, painful intercourse, and endometrial hardening, as well as reducing endometrial lesion size.

* Sex and gender exist on spectrums. Use of the term female in this article refers to sex assigned at birth.

Lupron Depot Vs Leuprolide Acetate

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Lupron Depot is a brand-name drug that contains the active drug leuprolide acetate. Lupron Depot doesnt come in a generic form. However, leuprolide acetate is available as a generic version of Lupron, which is a discontinued brand-name drug.

A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug.

Both Lupron Depot and leuprolide acetate belong to a drug class called gonadotropin releasing hormone agonists. They work by blocking your body from creating certain hormones, such as estrogen or testosterone. This can stop certain cells from growing, which can help treat certain conditions that are affected by hormones.

Lupron Depot and leuprolide acetate are both approved for palliative treatment of advanced prostate cancer. Lupron Depot is also approved for:

  • management of endometriosis, which includes reduction in endometriotic lesions and relief of pain associated with endometriosis
  • preoperative hematologic improvement of uterine fibroids when taken in combination with supplemental iron

Another form of this drug, Lupron Depot-Ped, is approved to treat central precocious puberty in children.

Lupron Depot is given every 1, 3, 4, or 6 months as an intramuscular injection. Its injected by a healthcare professional. Leuprolide acetate is a daily subcutaneous injection that you can self-inject after youve received training from a healthcare professional.

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Frequently Asked Questions About Lupron

Generic Name: Leuprolide Trade Name: Eligard®, Lupron®, Lupron Depot®, Viadur®

How is Lupron® used? Lupron is FDA approved for the treatment of advanced prostate cancer. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.

What is the mechanism of action? Lupron is classified as a luteinizing hormone releasing hormone agonist. LHRH is a naturally occurring hormone in the body that is involved in stimulating the production of female and male hormones such as estrogen and testosterone. Lupron inhibits the signaling of LHRH so that the production of estrogen or testosterone is reduced. Certain cancers, such as prostate cancer, are stimulated to grow from hormones. The reduction in the production of growth-stimulatory hormones inhibits the growth of cancer cells.

How is Lupron given ? Lupron is administered as an injection under the skin , into a muscle , or as an implantable device and the dose depends on several factors, including the condition being treated, the particular regimen being used and the overall health of the patient.

What are the common side effects of treatment with Lupron?

Hot flashes Impotence Erectile dysfunction

What are the less common side effects of treatment with Lupron?

Options In Hormone Therapy

Testosterone levels in the body can be reduced either surgically or with drugs. The surgical option is castration, achieved by removing the testicles during a bilateral orchiectomy. Once the only option, it has since been supplanted by drugs that lower testosterone levels to amounts achieved by surgery.

For men, normal testosterone levels range from 300 to 1,000 ng/dl. The FDA requires that any new drug used in hormone therapy for prostate cancer lower testosterone levels to 50 ng/dl or less. In my practice, I usually try to lower levels even further, to 20 ng/dl.

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Leuprolide Injection May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:

  • tiredness
  • hot flashes , sweating, or clamminess
  • breast tenderness, pain, or change in breast size in both men and women
  • vaginal discharge, dryness, or itching in women
  • spotting or menstruation
  • swelling of the hands, feet, ankles, or lower legs
  • pain, burning, or tingling in the hands or feet
  • pain, burning, bruising, redness, or hardening at place where injection was given
  • change in weight
  • runny nose, cough, sore throat, or flu-like symptoms
  • fever
  • unable to control emotions and frequent mood changes
  • nervousness
  • confusion
  • seizures

Leuprolide injection may cause a decrease in the density of your bones which can increase the chance of broken bones. Talk to your doctor about the risks of using this medication and to find out what you can do to decrease these risks.

In children receiving leuprolide injection for precocious puberty, new or worsening symptoms of sexual development may occur during the first few weeks of treatment. In girls receiving leuprolide injection for precocious puberty, the onset of menstruation or spotting may occur during the first two months of treatment. If bleeding continues beyond the second month, call your doctor.

Leuprolide injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .

Secondary Treatment Following Relapse

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Hormone therapy may also be used as a secondary or salvage treatment when PSA levels rise following initial prostate cancer treatment, indicating the cancer has returned. This situation is known as biochemical recurrence. The salient points to keep in mind are that hormone therapy is most often used as a salvage treatment when PSA doubling time is less than six months, indicating that the cancer is aggressive or may have already metastasized.

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Eligard For Prostate Cancer

The Food and Drug Administration approves prescription drugs such as Eligard to treat certain conditions. Eligard may also be used off-label for other conditions. Off-label drug use means using a drug for a purpose other than what its been approved for by the FDA.

Eligard is approved for use as a palliative treatment for advanced prostate cancer in adult males*. Palliative treatment means that the drug works to help manage pain and other symptoms of this condition. It wont treat or cure advanced prostate cancer, but it may help improve a persons quality of life.

* Use of the terms male and female within this article refers to a persons sex assigned at birth.

Lupron Depot For Palliative Treatment Of Advanced Prostate Cancer

Lupron Depot is FDA-approved as a palliative treatment for advanced prostate cancer in adults.

Lupron Depot contains the drug leuprolide acetate, which belongs to a class of drugs called gonadotropin releasing hormone agonists. It works by blocking your body from creating certain hormones, like testosterone. This can help stop prostate cancer cells from growing.

Effectiveness for advanced prostate cancer

In four clinical studies, males* with advanced prostate cancer were given Lupron Depot in various dosage schedules:

  • 7.5-mg injection every month for 6 months
  • 22.5-mg injection every 3 months for 6 months
  • 30-mg injection every 4 months for 8 months
  • 45-mg injection every 6 months for 1 year

The studies evaluated how much Lupron Depot could lower testosterone levels and stop prostate tumors from growing. In 93.4% to 95% of males, testosterone levels below 50 ng/dL were achieved within 4 weeks of the first injection, regardless of their dosage schedule.

The studies also looked at tumor growth. In 77% to 85% of males taking Lupron Depot, there was no tumor growth during the clinical studies.

* Sex and gender exist on spectrums. Use of the term male in this article refers to sex assigned at birth.

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Lupron Depot 30 Mg For 4

The recommended dose of LUPRON DEPOT 30 mg for 4-month administration is one injection every 16 weeks. Do not use concurrently a fractional dose, or a combination of doses of this or any depot formulation due to different release characteristics.

Incorporated in a depot formulation, the lyophilized microspheres must be reconstituted and should be administered every 16 weeks as a single intramuscular injection.

For optimal performance of the prefilled dual chamber syringe , read and follow the instructions in Section 2.5.

Tips For A Better Lupron Treatment Experience

Lupron Depot Injection

Making the choice to treat your advanced prostate cancer can have its rewards and its challenges. To help yourself have the best possible treatment experience, take an active role in your therapy. These suggestions may help.

  • If you start experiencing side effects, donât be silent. Talk to your doctor. He or she may have some ideas for helping to manage side effects. Its also important to let your healthcare team know if you experience new or worsening symptoms.

  • Stay committed to your LUPRON DEPOT therapy by going to all of your appointments. Get all the doses you are prescribed so you can get the most from your LUPRON DEPOT therapy.

  • If you miss an appointment, schedule another one as soon as you can. If scheduling is a problem, talk to your doctor about any options he or she may have.

  • Get monitored regularly to check your progress. During your scheduled visit, your Prostate Specific Antigen should be tested , and some doctors may also test your blood for testosterone levels to help your doctor determine how LUPRON DEPOT is working.1

Keep focused on the positive aspects of your life and the time you can spend with family and friends

Taking an active role in your treatment plan may help you feel more in control of what youâre going through.

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