Saturday, February 24, 2024

Natural Treatment For Chemo Induced Neuropathy

Therapeutic Effects: Herbal Medicine For Oral Dosage Form

Peripheral Neuropathy Treatment – Finding Relief from Chemotherapy Induced Peripheral Neuropathy

Here, two trials were investigated. One compared the bawei yangmai decoction and vitamin B12 . The other compared goshajinkigan granules combined with vitamin B12 and with vitamin B12 alone . The bawei yangmai decoction was found to improve the effectiveness rate in comparison to vitamin B12 . However, the goshajinkigan granules combined with vitamin B12 did not show a statistical difference between the two groups. Regarding QoL, the bawei yangmai decoction was found to improve the QoL, as assessed by the CACA form, in comparison with vitamin B12 . The goshajinkigan granules combined with vitamin B12 did not show a significant improvement on FACT-Taxane, in comparison to vitamin B12 alone. NCS was not reported.

Dietary Supplements To Alleviate Side Effects Of Cancer Treatment

Can I take antioxidants to prevent the side effects of cancer therapies?There are prescription drugs that act as antioxidants to help protect against the adverse effects of cancer therapies. The precise mechanism and the side effects of these drugs have been thoroughly examined. However, very few antioxidant dietary supplements have been studied for their safety and usefulness. Current information about the use of these products is confusing. Some think they help kill cancer cells or protect healthy cells from the damage caused by chemotherapy drugs or radiation therapy. But antioxidant supplements may also make these treatments less effective. Until more is known, it is wise to avoid them during chemotherapy.

I heard some herbal formulas can be used to treat the side effects of chemotherapy. Is that true?Herbs like Astragalus have immunomodulating effects. They have been studied in humans and have been shown to help reduce some of the adverse reactions induced by chemotherapy. However, they are not appropriate for all patients and larger clinical trials are needed to confirm their safety and efficacy.

What are phytoestrogens?These are herbs that have estrogen-like activities. A few popular examples include soy, red clover, flaxseed, and dong quai.

The 5 False Facts Your Doctor Mistakenly Promotes Natural Treatment For Chemo

The medical community is largely responsible for this misinformation being passed on to the suffering patient. In my view it is the job and responsibility of the family doctor to teach the patient about their neuropathy problem. It is also the doctors job to train the patient in what they can do to improve and manage their neuropathy case successfully.

===> How To End Peripheral Neuropathy < < <

Many neuropathy patients, suffering with foot or hand pain, tingling, numbness, burning, and other evasive and hard to describe neuropathy symptoms, dont even know the name of their condition! And while others do, that is essentially all they know. With this in mind I want to address some of the most commonly INCORRECT facts that suffering neuropathy patients have been told, or come to understand, due to the lack of patient education by the medical community.

1. Neuropathy comes with age, and there is nothing you can do about it.This statement is only partially correct, inasmuch as aging can contribute to the increased onset and intensity of the neuropathy condition. There are however, many simple techniques and procedures that any person can learn which will offset many of these effects of aging as they relate to peripheral neuropathy.

4. Neuropathy just gets worse with time, and you have to accept that you are stuck with it.

Natural Treatment for Chemo-Induced Neuropathy

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A Medline Search Strategy

  • #1. Exp Antineoplastic Agents/
  • #2. or or or cisplatin or carboplatin or oxaliplatin or bortezomib or docetaxel or paclitaxel or taxane or taxotere or or platinum or vincristine or or thalidomide or ).mp.
  • #4. Exp Peripheral Nervous System Disease/
  • #5. or CIPN or or Polyneuropath or ).mp.
  • #7. exp Drugs, Chinese herbal/
  • #8. exp Herbal Medicine/
  • #9. exp Plants, Medicinal/
  • #10. exp Medicine, Chinese Traditional/
  • #13. exp Randomized Controlled Trials as Topic/
  • #14. exp controlled clinical trials as topic/
  • #16. or/#13#15
  • #17. #3 and #6 and #12 and #16.

Immune Check Point Inhibitors

Acupuncture Plus Herbs Relieve Chemo Neurotoxicity

Although not directly neurotoxic, immune-mediated neuropathies occur inassociation with use of the newer classes of immune check point inhibitors,which are being used in the treatment of melanoma and increasingly other tumors.Ipilimumab and tremelimumab target the human cytotoxic T-lymphocyte-associatedantigen 4 , leading to activation of cytotoxic T lymphocyte attack oncancer cells. Pembrolizumab and nivolumab are novel immune enhancing monoclonalantibody treatments for cancer that target the PD-1 receptor, which regulates cell death in immunecells. A variety of neurological side effects have been reported with theseimmune check point inhibitors, including peripheral and central nervous systemdisorders, some of which are life threatening76, 77.The reported neuropathy cases often closely resemble acute or chronicinflammatory demyelinating neuropathies78 or vasculitic neuropathies79. Although they are considered as rare, theymay occur in up to 3% of patients76. Treatment of these side effects is discontinuation ofthe immune-enhancing chemotherapy and institution of immunotherapy , which is reported to be beneficial in many patients.

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Treatment And Prevention Of Cipn

Unfortunately, there are no preventative treatments for CIPN82, 83. It is challenging to understand why drugs directed towardskilling rapidly dividing cancer cells also target non-dividing, post-mitoticneurons. Developing CIPN-preventing agents is complicated by the concern that anyagent may also decrease the efficacy of the chemotherapeutic. Preventativestrategies must depend on either separating the mechanism of neurotoxicity from themechanism of cancer cytoxicity or identifying cell properties unique to neuronalcells . Despite intenseresearch efforts, this mechanism-based approach has not brought an effectivetreatment forward.

Another novel approach is to identify individual patient-specificmechanisms. Induced pluripotent stem cells derived from patient fibroblastsmay be used to generate specific neuron subtypes susceptible to CIPN such as dorsalroot ganglion neurons111. Theselines may then be used to predict susceptibility or therapeutic response of theindividual patient or to model and study disease mechanisms, so-called disease in adish112.

Treating Nerve Pain After Chemotherapy: An Option That Works

The antidepressant duloxetine has been found to help relieve neuropathic pain, a tingly feeling felt by many cancer survivors.

Once cancer treatment ends, a challenging and lasting side effect can remain: peripheral neuropathy, a tingling feeling usually felt in the toes, feet, fingers and hands.

For some, the sensation is uncomfortable, notes Ellen M. Lavoie Smith, Ph.D., an associate professor at the University of Michigan School of Nursing.

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But for about 30 percent of breast cancer patients, peripheral neuropathy is a painful sensation. People treated for gastrointestinal, urologic and other cancers can also be affected.

This problem stems from the cancer drugs causing damage to the peripheral and central nervous system structures. The damage can lead to lasting abnormalities in how the brain processes pain signals.

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Chemo Induced Peripheral Neuropathy

Disorders of peripheral nerves are frequent complications of chemotherapy and certain other drug therapies. As more and more effective therapies for cancer are found and patients are living longer, peripheral neuropathy complications of chemotherapy is increasing in prevalence. Chemotherapy can cause degeneration of peripheral sensory and motor nerves and cause patients to present with sensory disturbances, balance problems or weakness.

Preventive Effects: Herbal Medicine For Iv Infusion

Updates in Chemotherapy-Induced Neuropathy

One trial investigated the preventive effects of Astragali Radix through IV infusion in comparison to no treatment and to glutathione . Astragali Radix through IV infusion showed a significant reduction of the incidence rate and improvement of KPS in comparison to no treatment. However, in comparing Astragali Radix and glutathione, no significant differences were found in the incidence rate or the KPS.

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Natural Remedies For Neuropathy From Chemo

Many patients are averse to treating their condition with multiple medications as they fear complicating their recovery, or simply do not want to introduce different elements into their systems during cancer treatment.

In this case, these patients may instead opt for natural remedies for neuropathy from chemo. There are a good amount of holistic options when it comes to treating your CIPN symptoms. Of course, its important to confer with your doctor before trying any of the following treatments.

Lotions/Creams Patients have had some success in easing their peripheral neuropathy symptoms with botanical creams and lotions. As with any option, its important to verify that product claims are validated by prior usage and patient testimonials.

CamWells Hand to Heal cream is specifically formulated to be the best lotion for chemotherapy patients. The Hand to Heal herbal formula has been used for over 20 years and is based on the herb compatibility theory of natural medicine. Perhaps most importantly, the effectiveness of Hand to Heal has been proven through randomized, double-blind, placebo-controlled studies.

Patients using CamWells Hand to Heal cream for hand foot syndrome have reported the product helping ease their peripheral neuropathy symptoms as well.

Many patients find that walking for exercise is a convenient, easy activity that keeps them active and is quite enjoyable.

Upon completion of the study, 93% of the patients had complete resolution of their CIPN symptoms.

Acupuncture Plus Herbs Relieve Chemo Neurotoxicity

Details
04/15/2016

Acupuncture and herbs produce optimal positive patient outcomes for patients with peripheral neuropathy due to chemotherapy.

Research demonstrates that acupuncture and herbs alleviate pain and numbness of the arms and legs caused by the adverse effects of chemotherapy for patients with several types of cancer. The results demonstrate that a combined protocol of acupuncture and herbal medicine produces a 90% total effective rate for the relief of pain and numbness.

LI4 Needling

Acupuncture and Chinese herbal medicine alleviate extremity pain and numbness induced by chemotherapy neurotoxicity according to research published in the Shandong Medical Journal. Researchers investigated the efficacy of warm needle acupuncture combined with the oral intake of the herbal formula Huang Qi Gui Zhi Wu Wu Tang for the treatment of chemotherapy induced peripheral neuropathy. Based on the data, the researchers conclude that acupuncture combined with herbal medicine has a 90% total effective rate for the alleviation of chemotherapy induced peripheral neuropathy for patients with gastric, colorectal, lung, nasopharyngeal or breast cancer.

Chi Shao Yao

The herbs and acupuncture points used in the study are as follows. The herbal formula Huang Qi Gui Zhi Wu Wu Tang consisted of the following individual herbs:

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Approach To Peripheral Neuropathy In Patient With Cancer

When evaluating a patient with cancer that develops a neuropathy, determiningwhether they have CIPN requires an analysis of the administered drugs, thecumulative dosage, as well as the clinical characteristics and time course of theneuropathic symptoms. First, has the patient received a neurotoxicchemotherapeutic? The taxanes, platinum drugs, vinca alkaloids,thalidomide and bortezomib, all have a high likelihood of inducing CIPN. For someother drugs the likelihood is low withonly single cases reported in the literature. Second, it is important toconsider the route of drug administration. Methotrexate is rarelyassociated with neurological toxicity except when administeredintrathecally2. Bortezomibneurotoxicity decreases with subcutaneous administration3. Third, hasthe patient received a drug dose commensurate with developing CIPN?Symptoms of CIPN typically begin during the first two months of treatment, progresswhile chemotherapy continues, and then stabilize soon after treatment is completed.While most CIPN occurs in a dose dependent fashion, other drug-specific features maybe present such as the acute neurotoxicity of paclitaxel and oxaliplatin, or theworsening of neuropathy after discontinuation of cisplatin . It would beunexpected for CIPN to appear weeks or months after the last dose of neurotoxicchemotherapy treatment. Table 1 shows asummary of most commonly used drugs, and also estimates a cumulative dose associatedwith neuropathy for each drug when available.

What Can I Do To Deal With Cipn

Does Neuropathy from Chemo Go Away?

There are some things you can do to better manage the symptoms of CIPN, such as:

  • Talk to your doctor or nurse about the problems you are having in daily life. They might be able to suggest ways to make you feel better or function better.
  • If you are taking pain medicines, use them as your doctor prescribes them. Most pain medicines work best if they are taken before the pain gets bad. See Cancer Pain to learn more about pain, how to talk about it, and how to manage it.
  • Avoid things that seem to make your CIPN worse, such as hot or cold temperatures, or snug clothes or shoes.
  • Give yourself extra time to do things. Ask friends for help with tasks you find hard to do.
  • Dont drink alcohol. It can cause nerve damage on its own, and might make CIPN worse.
  • If you have diabetes, control your blood sugar. High blood sugar levels can damage nerves.
  • Talk to your doctor or nurse about whether it is safe for your to exercise. A physical therapist can make suggestions for what might be most helpful to you.
  • If constipation is a problem, follow your doctors recommendations about laxatives and exercise. Drink plenty of water and eat fruits, vegetables, and whole grains to get enough fiber.
  • If the neuropathy is in your feet, sit down as much as possible, even while brushing your teeth or cooking.
  • If your neuropathy is permanent, your doctor may refer you to an occupational therapist . They are experts who help people lead more normal lives despite physical limits.

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Natural Approaches To Chemotherapy

One of the unfortunate possible long term side effects of receiving chemotherapy drugs is a condition called chemotherapy-induced peripheral neuropathy or CIPN. It is estimated that 30-40 % of patients that receive chemotherapy will have some degree of CIPN. Chemotherapy drugs can cause injury to nerve endings which typically lead to symptoms of burning, numbness, tingling, abnormal sensations and/or pain in the hands and feet. In more severe cases it can cause issues with balance, walking and use of ones hands. This can be a very debilitating condition for those who are affected by it.

The conventional approach to managing neuropathy is to prescribe nerve medications like gabapentin or pregabalin. These medications can help decrease the severity of pain but typically they do not improve sensation. Physical therapy is also a standard treatment that is beneficial in decreasing symptoms of CIPN by improving both pain and function in the affected areas.

There are also a number of complimentary therapies that have shown promise in helping patients who suffer from CIPN.

  • Dietary Supplements have been of interest in helping to improve CIPN symptoms. There has some been some controversy around their use. Certainly, all supplements should be cleared by your treating physician before starting. I generally recommend a trial of at least 90 days of the following supplements to see if they are helpful.
  • About Heidi Rula, M.D.

    Medical Director of the Supportive Care Services Department

    Dietary Supplements For Cancer Prevention

    What are free radicals? Do they cause cancers?Free radicals are chemicals that have unpaired electrons. They are present in the environment and are also generated in the body through normal metabolism. Free radicals are highly active and are thought to interact with DNA causing cell damage and cancer.

    What are antioxidants?Antioxidants are substances that can inhibit the process of oxidation associated with free radicals. Many foods and dietary supplements, such as vitamin C and pycnogenol, have antioxidant effects.

    Can antioxidants be used to prevent cancers?Some believe a diet rich in antioxidants helps prevent cancer. However, there is no conclusive evidence that antioxidant supplements can reduce cancer incidence. Moreover, high intake of certain antioxidants is associated with increased cancer risk.

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    Data Extraction And Assessment Of Methodological Quality

    The two authors assessed the titles and abstracts of the studies retrieved from electronic databases and each determined their eligibility for inclusion independently. Hard copies of the relevant studies were retrieved and then the authors used a standard data extraction form to extract the data independently. The form included methodology, participants, intervention, periods of treatment, outcomes, and conclusions. The two authors assessed the risk of bias using the Cochrane risk of bias tool and the following items: random sequence generation , allocation concealment , blinding of participants and personnel , blinding of outcome assessment , incomplete outcome data , selective outcome reporting , and other biases. We evaluated the domains as Yes,No, or Unclear, according to the Cochrane risk of bias criteria. When there was a discrepancy among the reviewers, a consensus was reached through discussion.

    The 5 False Facts Your Doctor Mistakenly Promotes Natural Relief From Chemo Induced Neuropathy

    Chemotherapy Induced Peripheral Neuropathy Clinical Trial

    The medical community is largely responsible for this misinformation being passed on to the suffering patient. In my view it is the job and responsibility of the family doctor to teach the patient about their neuropathy problem. It is also the doctors job to train the patient in what they can do to improve and manage their neuropathy case successfully.

    ===> How To End Peripheral Neuropathy < < <

    Many neuropathy patients, suffering with foot or hand pain, tingling, numbness, burning, and other evasive and hard to describe neuropathy symptoms, dont even know the name of their condition! And while others do, that is essentially all they know. With this in mind I want to address some of the most commonly INCORRECT facts that suffering neuropathy patients have been told, or come to understand, due to the lack of patient education by the medical community.

    1. Neuropathy comes with age, and there is nothing you can do about it.This statement is only partially correct, inasmuch as aging can contribute to the increased onset and intensity of the neuropathy condition. There are however, many simple techniques and procedures that any person can learn which will offset many of these effects of aging as they relate to peripheral neuropathy.

    4. Neuropathy just gets worse with time, and you have to accept that you are stuck with it.

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