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Pancreatic Cancer Survival Rate After Surgery

Variation In Pancreatic Cancer Treatment And Care

Whipple Procedure Survival Rate/Pancreatic Cancer Surgery

Depending on where someone diagnosed with pancreatic cancer receives care, their experience can be very different there can be different diagnostic pathways, different standards of care and different approaches to treatment.

Geographically, variation in treatment and care exists at all levels. There is international survival variation across developed countries, regional treatment variation across Cancer Alliances, and local variation in clinical practice between hospitals.

Where Is The Whipple Procedure Performed

The Whipple procedure is a complex operation with a high risk of major complications. It takes a lot of skill and experience to perform the surgery and manage any complications. To get the best outcome, youll want to have a very experienced surgeon and be in a hospital that performs at least 15-20 Whipple procedures each year.

Access To Pancreatic Cancer Treatment

Surgery is the only treatment with curative intent for pancreatic cancer while chemotherapy and radiotherapy have also been shown to improve survival in late stage pancreatic cancer. However, most people with pancreatic cancer will receive no active treatment .

7 in 10 people with pancreatic cancer do not receive any active treatment.

1 in 10 people with pancreatic cancer will receive potentially curative surgery.

2 in 10 people will receive chemotherapy.

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How Does Survival Rate Depend On Stage At Diagnosis

Fiveyear pancreatic cancer relative survival rates are 37% for patients with localized disease , 12% for patients with regional disease , and 3% for those with distant pancreatic cancer. Pancreatic cancer is most often diagnosed at an advanced stage 53% of patients are diagnosed with stage 4 pancreatic cancer, whereas only 10% of patients are diagnosed at the early stage when surgery is possible. Because the majority of patients are diagnosed at stage 4, which has the lowest survival rate, the overall survival rate for all stages is 9%lower than the average survival rate of all the stages.

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Univariable And Multivariable Analysis Of Factors Associated With Lts

Frontiers

We examined factors associated with LTS in both univariable and multivariable logistic regression . When considering patients of all stages, age, gender, T-stage, M-stage, tumour size, histological grade, surgical resection and chemotherapy were identified as independent predictors of LTS. Subgroup analyses were performed to determine whether the predictive factors were different between resected and non-resected patients. For surgically resected patients, age, gender, TNM-stage, tumour size, grade, and chemotherapy remained as significant independent predictors of LTS. In non-resected patients, only age, TNM-stage and grade were independent predictors of LTS.

Table 3 Univariable and multivariable logistic regression analyses of factors associated with long-term survivors .

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Results Of Univariate And Multivariate Analyses

In the univariate analysis, stratification factors, such as race, sex, year of diagnosis, pathological grade, AJCC stage, historic stage, tumour location, and age were used to evaluate PCSS and calculate the five-year PCSS. All of these factors, except sex, were significantly associated with PCSS .

In multivariate analysis, all significant stratification factors were included in the Cox model . Race and sex were not found to be prognostically important for assessing the survival of PC patients. Additionally, recent diagnosis of PC was found to be associated with a better survival than diagnosis in previous years. Undoubtedly, PC patients with tumours of higher grades had a higher risk of death than did those with tumours of pathological grade I/II. Likewise, advanced PC patients in stage III/IV or with distant organ involvement had a much poorer prognosis than did those outside this grouping. Compared with tumours in the head, tumours localized in the body and tail of the pancreas appeared to be associated with a favourable prognosis. Finally, the mortality risk of PC patients aged between 40 and 80 years was twice that of the patients aged below 40 years. However, patients aged > 80 years had a mortality risk three times higher than that of patients aged < 40 years. Therefore, age was an independent factor for predicting the prognosis of PC patients.

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Facts About The Pancreatic Cancer Survival Rate

Of course, a patient might be interested in learning as much as he or she can about the condition, including its pancreatic cancer survival rate. The following points hold true regarding the prognosis for pancreatic cancer:

  • An early and accurate diagnosis and prompt, appropriate treatment can improve a patients outlook.
  • Patients who undergo surgery tend to experience better outcomes than patients who are treated nonsurgically.
  • All other things being equal, a newly diagnosed cancer patient can potentially experience a better outcome than a patient who was diagnosed several years ago due to recent scientific developments.
  • Many individual factors can influence pancreatic cancer outcomes, such as a patients overall health and wellness.

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What Can Patients Do To Improve Their Chances

Pancreatic cancer patients who participate in clinical research have better outcomes. Seeing pancreatic cancer specialists, including healthcare professionals who focus on symptom management and supportive care also improves outcomes. And, patients who receive treatment based on their biology can live longer.

For all stages, the Pancreatic Cancer Action Network strongly recommends:

  • Clinical trials at diagnosis and during every treatment decision
  • Genetic testing for inherited mutations as soon as possible after diagnosis and biomarker testing of tumor tissue to help determine the best treatment options
  • Getting an opinion from a specialist, a physician who diagnoses and treats a high volume of pancreatic cancer patients
  • Symptom management and supportive care, provided early in your diagnosis as well as during and after treatment

Contact PanCAN Patient Services to learn more about these options.

What Is Pancreatic Cancer

What is the Survival Rate of Pancreatic Cancer?

This type of cancer is caused by a growth in your pancreas. The tumor usually grows in the head, neck or body of your pancreas. Few grow in the tail. Pancreatic cancer is primarily caused by smoking and most of those diagnosed are between the ages of 60 and 80 years.

Yearly in the U.S., about 57,000 people are diagnosed with pancreatic cancer and there are around 46,000 deaths. Only roughly 8.5% of people with this type of cancer live for another five years after their diagnosis.

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What Should I Expect After The Whipple Procedure

The Whipple procedure is a significant surgery. Recovery from the procedure will take some time.

Youll have pain for a while after your Whipple procedure. During your hospital stay, your care team will manage your pain and watch for signs of infection or other complications. Youll be on a clear, liquid diet for a few days until your healthcare providers feel that youre ready to introduce solid foods. As soon as you feel up to it, you should start doing lung exercises and moving about your room just be sure to call a nurse or physical therapist for help getting up so you dont fall.

What Is Locally Advanced Pancreatic Cancer

Locally advanced pancreatic cancer is considered stage 3 cancer. It is cancer that has spread beyond the pancreas, typically to large blood vessels near the pancreas or to nearby lymph nodes. In most cases, the cancer is too advanced to be fully removed. Treatment for locally advanced pancreatic cancer is highly individualized based on the patients overall health, tumor spread and personal desires, but may include:

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Anatomic Site Functional Performance Status

The anatomic distribution of all stages of pancreatic cancer and MPC are detailed in Figure 2. Of note, while the head of the pancreas constitutes 6,506 cases of all cancers identified, only 2,656 cases originated at this site among patients with MPC. The tail of the pancreas constituted 4.6% more cases of MPC compared to pancreatic cancer at all stages.

Figure 2

The functional performance status as calculated by the ECOG-PS score is shown in Figure 3 for all stages. The other established system of ranking performance status, the Karnofsky Performance Status was used in a negligible number of charts. The functional status appears to trend down as the stage at diagnosis advances. For example, 36.41% of stage I patients have a functional ECOG-PS score of 0 while only 20% of stage IV patients have an ECOG-PS of 0. For stage I patients, 7.04% of patients had an ECOG-PS score of 3, and 14.39% of patients diagnosed at stage IV had this ECOG-PS score.

Figure 3

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How Are Survival Rates Determined

Pancreatic Cancer Survival rates in England increase significantly in ...

In the United States, cancer survival rates are calculated with data collected by the National Cancer Institutes Surveillance, Epidemiology, and End Results program. SEER collects data on all types of cancers from different geographical locations and sources throughout the country. While it is not yet feasible to obtain data for every single patient in the U.S., SEER data covers large proportions of the countrys population and can be statistically analyzed to make reasonably accurate estimates of overall cancer survival rates.

The SEER program began collecting cancer data in 1973 in seven cancer registriessystems for collecting and managing cancer datarepresenting five states and two metropolitan areas. Since then, more registries representing different geographical locations have been added, and to date, 21 registries have collected cancer data through SEER. Different databases represent groups of these registries in different combinations used to analyze survival data and other statistics.

Sometimes survival rates vary slightly based on the SEER database used. For example, pancreatic cancer five-year survival is reported to be 10% when using the SEER 9 database which contains 9 registries and represents about 9% of the U.S. population, but it is reported to be 9% when using SEER 18, which contains 18 registries and represents about 28% of the population.

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What Is The Outlook For Pancreatic Cancer

Over the past decade, the five-year survival rate for pancreatic cancer patients increased from 6% to 11%.2 There is an urgent need to improve survival even more. But this increase shows that progress is being made. Those five percentage points mean that 11 people out of 100, instead of six people out of 100, will be alive five years after their pancreatic cancer diagnosis.

The Pancreatic Cancer Action Network is working toward better treatment options for pancreatic cancer patients and ways to find the disease earlier. We are determined to improve patient outcomes today and into the future. Contact PanCAN Patient Services for resources, support and information.

How Is Pancreatic Cancer Staged

Pancreatic cancer is usually staged differently than other types of cancers. While many cancers are staged using the TNM system, which categorizes tumors based on diagnostic tests and classifications that happen during surgery, many patients with pancreatic cancer dont have surgery, so the TNM system isnt used as often to stage these diseases.

Instead, pancreatic cancer tumors are more often classified into one of four categories based on where they have spread and whether theyre able to be removed during surgery. The categories are as follows:

Resectable

This type of cancer hasnt spread outside the pancreas or has only gone just past it. Resectable cancer can be removed by surgery.

Borderline resectable

With this type of pancreatic cancer, the tumor may, when first diagnosed, appear to be too difficult to remove surgically. However, surgery may still be an option if the tumor can be reduced in size through radiation therapy or chemotherapy treatment.

Locally advanced

Locally advanced cancer has spread just beyond the pancreas and may have reached nearby arteries, veins or organswhich means surgery is not an option. However, it hasnt spread into more distant areas of the body.

Metastatic

Metastatic cancer has spread beyond the pancreas into distant areas of the body, such as the liver, abdomen or lungs. If youve been diagnosed with pancreatic cancer, your care team will let you know the stage of your cancer, along with what it means for your treatment plan.

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Outcomes Of Resected Pancreatic Cancer In Patients Age 70

Thomas J. Hayman1, Tobin Strom2, Gregory M. Springett3, Lodovico Balducci4, Sarah E. Hoffe2, Kenneth L. Meredith5, Pamela Hodul3, Mokenge Malafa3, Ravi Shridhar2

1 University of South Florida Morsani College of Medicine, Tampa, FL, USA Senior Adult Oncology Program, Moffitt Cancer Center, Tampa, FL, USA Gastrointestinal Oncology, Sarasota Memorial Hospital, Sarasota, FL, USA

Contributions: Conception and design: All authors Administrative support: None Provision of study materials or patients: None Collection and assembly of data: T Strom Data analysis and interpretation: T Strom Manuscript writing: R Shridhar, TJ Hayman Final approval of manuscript: All authors.

Correspondence to:

Objective: To determine outcomes of patients 70 years with resected pancreatic cancer.

Methods: A study was conducted to identify pancreatic cancer patients 70 years who underwent surgery for pancreatic carcinoma from 2000 to 2012. Patients were excluded if they had neoadjuvant therapy. The primary endpoint was overall survival .

These data show that in patients 70, nodal status, post-op CA19-9, and adjuvant chemoradiation, were associated with OS. The data suggests that outcomes of patients 70 years who undergo upfront surgical resection are not inferior to younger patients.

Keywords: Pancreatic cancer surgery elderly adjuvant therapy chemoradiation

Submitted Feb 09, 2015. Accepted for publication Feb 28, 2015.

doi: 10.3978/j.issn.2078-6891.2015.038

Signs That Pancreatic Cancer Has Spread

Surviving Pancreatic Cancer

If your pancreatic cancer has spread, you may notice new symptoms. Most often, pancreatic cancer spreads to the liver, but it can also move into the lymph nodes, abdomen, lungs and, sometimes, the bones.

Advanced pancreatic cancer symptoms may include:

  • General feeling of being unwell
  • Swollen stomach caused by fluid buildup
  • Lack of appetite

If you experience any of these symptoms, check with your doctor to determine a cause. Also, keep in mind that these symptoms may be due to other conditions.

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Overall Survival For Pancreatic Cancer

The overall one-year survival rate for pancreatic cancer is 24.4%, in the UK. This means that around 24 in 100 will have survived to one year and beyond.

The five-year survival rate for pancreatic cancer is 7.3%. This means that around 8 in 100 people will have survived for five years and beyond.

10-year survival of the disease is 1%, meaning only around 1 in 100 people survive 10 years and beyond.

Pancreatic cancer has the lowest five-year survival rate of any of the 22 common cancers. However, it is encouraging that survival has more than doubled since Pancreatic Cancer Action began, 10 years ago. Though increases in survival may seem small, we are beginning to see a slow but positive trend upwards after decades without improvement.

Survival Statistics For Pancreatic Cancer

Survival statistics for pancreatic cancer are very general estimates and must be interpreted very carefully. Because these statistics are based on the experience of groups of people, they cannot be used to predict a particular persons chances of survival.

There are many different ways to measure and report cancer survival statistics. Your doctor can explain the statistics for pancreatic cancer and what they mean to you.

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Fewer Than Half Of The Survivors Remained Recurrence

byCharles Bankhead, Senior Editor, MedPage Today November 19, 2021

More than a fourth of patients with early-stage pancreatic cancer remained alive at 5 years, although fewer than half of the survivors were disease-free, data from a large surgical series showed.

Following upfront surgery for pancreatic ductal adenocarcinoma , 48 of 176 patients lived 5 years or longer, including 20 who survived at least 5 years without recurrence. Median post-recurrence survival was 12 months. The cohort had a median disease-specific survival of 36 months. In a multivariable analysis, absence of perineural invasion was the only favorable independent predictor of survival beyond 5 years.

The findings, which reflected actual or observed survival as opposed to estimates, confirmed that patients with favorable tumor characteristics can achieve long-term survival with upfront surgery and adjuvant chemotherapy, reported Stefano Crippa, MD, PhD, of the Universitá Vita-Salute in Milan, and co-authors in Annals of Surgical Oncology.

The trial represents an important contribution to the PDAC literature by providing data on actual survival as opposed to actuarial survival reported from most clinical trials, said the authors of an accompanying editorial. However, the study has limited applicability to contemporary clinical practice because of the use of single-agent adjuvant gemcitabine, which is no longer standard or commonly used.

Disclosures

Where Do These Numbers Come From

Department of Hepatobiliary and Pancreatic Surgery

The American Cancer Society relies on information from the SEER* database, maintained by the National Cancer Institute , to provide survival statistics for different types of cancer.

The SEER database tracks 5-year relative survival rates for pancreatic cancer in the United States, based on how far the cancer has spread. The SEER database, however, does not group cancers by AJCC TNM stages . Instead, it groups cancers into localized, regional, and distant stages:

  • Localized: There is no sign that the cancer has spread outside of the pancreas.
  • Regional: The cancer has spread from the pancreas to nearby structures or lymph nodes.
  • Distant: The cancer has spread to distant parts of the body such as the lungs, liver or bones.

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Survival Rates For Pancreatic Neuroendocrine Tumor

Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time after they were diagnosed. They cant tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful.

Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they cant predict what will happen in any particular persons case. These statistics can be confusing and may lead you to have more questions. Your doctor is familiar with yoursituation ask how these numbers may apply to you.

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