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Stage 1 Bladder Cancer Survival Rate

Treating Stage Iii Bladder Cancer

Treating Early Stage Bladder Cancer

These cancers have reached the outside of the bladder and might have grown into nearby tissues or organs and/or lymph nodes . They have not spread to distant parts of the body.

Transurethral resection is often done first to find out how far the cancer has grown into the bladder wall. Chemotherapy followed by radical cystectomy is then the standard treatment.Partial cystectomy is rarely an option for stage III cancers.

Chemotherapy before surgery can shrink the tumor, which may make surgery easier. Chemo can also kill any cancer cells that could already have spread to other areas of the body and help people live longer. It can be especially useful for T4 tumors, which have spread outside the bladder. When chemo is given first, surgery to remove the bladder is delayed. The delay is not a problem if the chemo shrinks the cancer, but it can be harmful if it continues to grow during chemo. Sometimes the chemo shrinks the tumor enough that intravesical therapy or chemo with radiation is possible instead of surgery.

Some patients get chemo after surgery to kill any cancer cells left after surgery that are too small to see. Chemo given after cystectomy may help patients stay cancer-free longer, but so far its not clear if it helps them live longer. If cancer is found in nearby lymph nodes, radiation may be needed after surgery. Another option is chemo, but only if it wasn’t given before surgery.

How Does Recurrence Of Bladder Cancer Affect Survival Rate

Recurrent bladder cancer is cancer that has returned after initial treatment. Recurrence rates for bladder cancer depend on the stage of the original tumor, with 5-year recurrence rates of approximately 65% in patients with non-invasive or in situ tumors and 73% in patients with slightly more advanced disease at first diagnosis.16

Many patients with non-invasive bladder cancer have recurrences that are typically not life threatening however, the prognosis is generally worse if the disease has spread into deeper layers of the bladder wall or beyond to the lymph nodes or other organs.

What Are The 5

In 2020, approximately 17,980 deaths in the United States are predicted to be attributed to bladder cancer1. This represents the eighth most common cause of cancer deaths in men.

The general 5-year survival rate for people with bladder cancer is 77%, while the 10-year survival rate is 70% and the 15-year survival rate is 65%1. Notably, as each patient and cancer are different, it is not possible to definitely know the disease course for an individual patient.

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How Long Will You Live If You Have Bladder Cancer

The survival rate depends on the stage of cancer at diagnosis and other health issues.

Overall, 70 to 90 percent of people with localized bladder cancer will live for at least five years or more. The physician calculates this with the help of survival rates. Survival rates indicate the percentage of people who live with a certain type of cancer for a specific time. The physician often uses an overall five-year survival rate. Factors that may affect survival rate include

Table. Five-year survival rates of different stages of bladder cancer

Bladder cancer SEER stages Five-year relative survival rate
In situ alone 96
All SEER stages combined 77

The surveillance, epidemiology, and end results stages are taken from the SEER database, maintained by the National Cancer Institute. SEER database groups cancers into localized, regional, and distant stages.

  • Localized: There is no indication that cancer has spread outside the bladder.
  • Regional: Cancer has invaded the nearby structures or lymph nodes.
  • Distant: Cancer has spread to distant parts of the body, such as the lungs, liver, or bones.

Thus, bladder cancer, if detected in the early stage is treatable and has higher survival rates. However, if the cancer is detected in the advanced stages, treatment becomes difficult and the survival rate is low.

Occurrence In The United States

Stage 2 Bladder Cancer Survival Rate

The American Cancer Society estimates that 81,180 new cases of bladder cancer will be diagnosed in the United States in 2022 and that 17,100 people will die of the disease. The incidence of bladder cancer increases with age, with the median age at diagnosis being 73 years bladder cancer is rarely diagnosed before age 40 years.

Bladder cancer is about 4 times more common in men than in women. The male predominance in bladder cancer in the United States reflects the prevalence of transitional cell carcinoma . With small cell carcinomain contrast to TCCthe male-to-female incidence ratio is 1:2.

Bladder cancer is the fourth most common cancer in men in the United States, after prostate, lung, and colorectal cancer, but it is not among the top 10 cancers in women. Accordingly, more men than women are expected to die of bladder cancer in 2022, with 12,120 deaths in men versus 4980 in women. Nevertheless, women generally have a worse prognosis than men.

The incidence of bladder cancer is twice as high in White men as in Black men in the United States. However, Blacks have a worse prognosis than Whites.

Limited data indicate that small cell carcinoma of the urinary bladder probably has the same epidemiologic characteristics as urothelial carcinoma. Patients are more likely to be male and older than 50 years.

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Causes And Risk Factors

Researchers dont know exactly what causes bladder cancer, but they do know what increases the risk of getting it. These risk factors range from family history to certain types of medication.

Source: Valisure

Data published in 2021 on MedRxiv by researchers from the online pharmacy Valisure and Memorial Sloan Kettering Cancer Center showed patients who took Zantac had elevated diagnosis rates of bladder, breast, prostate and thyroid cancer.

Patients should keep in mind that this data suggests a link between ranitidine and increased risk, but it doesnt prove that all people who take ranitidine will get bladder cancer.

Certain Factors Affect Prognosis And Treatment Options

The prognosis depends on the following:

  • The stage of the cancer . Bladder cancer in the early stages can often be cured.
  • The type of bladder cancer cells and how they look under a microscope.
  • Whether there is carcinoma in situ in other parts of the bladder.
  • The patients age and general health.

If the cancer is superficial, prognosis also depends on the following:

  • How many tumors there are.
  • The size of the tumors.
  • Whether the tumor has recurred after treatment.

Treatment options depend on the stage of bladder cancer.

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Genetic Factors In Pathogenesis

Divergent, yet interconnected and overlapping, molecular pathways are likely responsible for the development of noninvasive and invasive bladder tumors. Somatic mutations in fibroblast growth receptor3 and tumor protein p53 in tumor cells appear to be important early molecular events in the noninvasive and invasive pathways, respectively.

FGFR-3, Ras, and PIK3CA mutations occur with high frequency in noninvasive tumors, leading to upregulation of Akt and mitogen-activated protein kinase . Loss of heterozygosity on chromosome 9 is among the most frequent genetic alterations in bladder tumors and is considered an early event.

Large numbers of genomic changes have been detected using karyotyping and comparative genomic hybridization analysis in urothelial carcinoma. Numerically common are losses of 2q, 5q, 8p, 9p, 10q, 18q, and Y. Gains of 1q, 5p, 8q, and 17q are frequently present, and high-level amplifications can be found however, the target genes in the regions of amplifications have not been conclusively identified.

Alterations in the TP53 gene are noted in approximately 60% of invasive bladder cancers. Progression-free survival is significantly shorter in patients with TP53 mutations and is an independent predictor of death among patients with muscle-invasive bladder cancer.

How Do I Take Care Of Myself

Bladder Cancer Statistics | Did You Know?

About half of all people with bladder cancer have early-stage cancer thats relatively easy to treat. But bladder cancer often comes back . People whove had bladder cancer will need regular checkups after treatment. Being vigilant about follow-up care is one thing you can do to take care of yourself. Here are some other suggestions from the Bladder Cancer Advocacy Network include:

  • Follow a heart-healthy diet: Plan menus that include skinless poultry and fish, low-fat dairy products, nuts and legumes, and a variety of fruits and vegetables.
  • Focus on high-fiber foods: Bladder cancer treatment may cause digestive issues and a fiber-rich diet may help.
  • Get some exercise: Gentle exercise may help manage stress.
  • Connect with others: Bladder cancer often comes back. Its not easy to have a rare disease thats likely to return. Connecting with people who understand what youre going through may help.

Urinary diversion

Some people with bladder cancer need surgery that removes their bladder and their bodies natural reservoir for pee. There are three types of urinary diversion surgeries. All three types involve surgically converting part of your intestine to become a passage tube for pee or a reservoir for storing pee.

Urinary diversion may be a challenging lifestyle change. If youll need urinary diversion surgery, ask your healthcare provider to explain each surgery types advantages and disadvantages. That way, youll know what to expect and how to take care of yourself.

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Survival For All Stages Of Bladder Cancer

Generally, for people diagnosed with bladder cancer in England:

  • around 75 out of every 100 survive their cancer for 1 year or more after diagnosis
  • almost 55 out of every 100 survive their cancer for 5 years or more after they are diagnosed
  • around 45 out of every 100 survive their cancer for 10 years or more after diagnosis

Cancer survival by stage at diagnosis for England, 2019Office for National Statistics

These statistics are for net survival. Net survival estimates the number of people who survive their cancer rather than calculating the number of people diagnosed with cancer who are still alive. In other words, it is the survival of cancer patients after taking into account that some people would have died from other causes if they had not had cancer.

Latest Treatment For Bladder Cancer

Intravesical therapy is a newer treatment for people who have bladder cancer. With intravesical therapy, the doctor puts a liquid medication right into your bladder rather than administering it orally or injecting it into your blood. The medication is put in through a catheter thats placed into your bladder through the urethra. The medication stays in your bladder for up to two hours, so it can affect the cells lining the inside of the bladder without having major effects on other parts of your body. Intravesical therapy is commonly used after transurethral resection of bladder tumor . Its often performed within 24 hours of the TURBT procedure. The goal is to kill any cancer cells that may be left in the bladder.

Intravesical chemotherapy is used to treat non-invasive bladder cancer. It is used for these early-stage cancers because medication given this way mostly affects the cells lining the inside of the bladder. It has little to no effect on cells elsewhere. This means any cancer cells outside of the bladder lining are not treated by intravesical chemotherapy.

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Stages Of Bladder Cancer: What You Need To Know

When you are first diagnosed with bladder cancer, your doctors will perform tests to determine the stage and grade of your disease. The bladder cancer staging and grading processes help your doctors make treatment decisions and estimate your chance of recovery.

Bladder cancer is a growth that starts in the inner wall of the bladder, the organ that collects and expels urine created by the kidneys. The bladder has three layers of muscular walls that make up its structure. A cancerous growth in the bladder can grow uncontrollably and start spreading to other parts of the body.

Verywell / Laura Porter

When doctors first diagnose a cancerous tumor of any kind, they assess how much it has grown, how far it has spread in the body, and how abnormal, or wild, the cancerous cells in the tumor look. These assessments are used to determine cancers stage and grade.

Doctors use the staging information to compare treatment options and patient outcomes. Staging and grading also important in determining your eligibility for cancer treatment clinical trials.

What Are The Survival Rates For Bladder Cancer

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If the cancer is just on the inner lining of the bladder , the 5-year survival rate is about 98%.

If the cancer is growing just beyond the inner lining into the bladder wall, but is still just in the bladder , the 5-year survival rate is about 88%.

Those with bladder cancer that’s spread into the muscular wall of the bladder, but not outside the bladder, or to nearby lymph nodes or organs have a 5-year survival rate of about 63%.

If the cancer has spread through the bladder muscle into the layer of tissue around the bladder and maybe to nearby organs , but has not spread to lymph nodes or other organs , the 5-year survival rate is about 46%.

When bladder cancer has moved beyond the bladder to the pelvic or abdominal wall, to lymph nodes, or to distant parts of the body , the 5-year survival rate is about 15%.

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What Are The Stages Of Bladder Cancer

Healthcare professionals describe the cancer by assigning numbers and/or letters to each of the three staging categories. This helps to identify the best treatment options for a patients specific type of bladder cancer. The five overall stages of bladder cancer are: stage 0, stage I, stage II, stage III, and stage IV.

Can Bladder Cancer Be Cured

When detected at an early stage, bladder cancer can usually be treated successfully whereas later-stage cancers may present greater challenges for the patient and their healthcare team. As discussed later, people who have had bladder cancer are at risk for recurrence for the best chance of successfully treating recurrent cancer, early detection is again important.

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Treatment Of Stage Iv Bladder Cancer

For information about the treatments listed below, see the Treatment Option Overview section.

Treatment of stage IV bladder cancer that has not spread to other parts of the body may include the following:

Treatment of stage IV bladder cancer that has spread to other parts of the body, such as the lung, bone, or liver, may include the following:

  • External radiation therapy as palliative therapy to relieve symptoms and improve quality of life.
  • Urinary diversion or cystectomy as palliative therapy to relieve symptoms and improve quality of life.
  • Aclinical trial of new anticancer drugs.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Low Grade And High Grade Bladder Cancer

Grading/Staging of Bladder Cancer

Bladder cancer starts in the lining of the bladder in about 90 percent of people diagnosed with this cancer. Bladder cancer is called low grade or high grade.

  • Low-grade bladder cancer means the cancer has not invaded the muscles around the bladder . People rarely die from this type of bladder cancer, it often recurs after treatment.
  • High-grade bladder cancer also often recurs and has a higher chance of spreading to other parts of the body. Almost all deaths from bladder cancer result this type so it is treated more aggressively.

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After Bladder Cancer Has Been Diagnosed Tests Are Done To Find Out If Cancer Cells Have Spread Within The Bladder Or To Other Parts Of The Body

The process used to find out if cancer has spread within thebladder lining and muscle or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage in order to plan treatment. The following tests and procedures may be used in the staging process:

Is Bladder Cancer Treatable

Many types of therapy are used to treat bladder cancer. In general, the treatment pathway chosen depends on the type and stage of bladder cancer present and a patients overall health and individual preferences. Common treatment options include:

  • Surgery: to remove tumor cells and surrounding tissue. The type of surgery used depends on factors such as the size and progression of the tumor.
  • Chemotherapy: which refers to the use of drugs to destroy cancer cells. Chemotherapy may be local or systemic .
  • Immunotherapy: which uses naturally occurring or man-made substances to improve or bolster the bodys immune system function. Like with chemotherapy, immunotherapy may be delivered locally or systemically.
  • Radiation therapy: which uses x-rays or other high-energy waves or particles to kill cancer cells.

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How Do You Prevent Bladder Cancer

Unfortunately, there is no one way to prevent bladder cancer. Some things like age, race, gender and genetics or family history cant be controlled. However, people can take steps to reduce their risk.

Tips for bladder cancer prevention include:

  • Quit or dont start smoking
  • Limit chemical exposure on the job
  • Drink plenty of fluids, especially water
  • Eat a diet high in fruits and vegetables

Treatment Of Recurrent Bladder Cancer

JPMA

For information about the treatments listed below, see the Treatment Option Overview section.

Treatment of recurrentbladder cancer depends on previous treatmentand where the cancer has recurred. Treatment for recurrent bladder cancer mayinclude the following:

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

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