Sunday, March 3, 2024

Stage 3 Cervical Cancer Life Expectancy

Why Choose The University Of Kansas Cancer Center For Cervical Cancer Treatment

Cervical Cancer Stage 0 1 2 3 4 Treatment, Survival Rate and Life Expectancy

If you are diagnosed with cervical cancer, the gynecologic oncology team at The University of Kansas Cancer Center provides comprehensive and personalized care. Our cancer center is a National Cancer Institute-designated cancer center, 1 of just 71 in the nation.

We provide you with all the resources youll need. The gynecologic oncologist coordinates all of your cervical cancer care, including surgery and clinical trials. Specialized gynecologic pathologists and radiologists provide expert diagnosis, and if you have any questions or problems, the registered nurse clinician or nurse practitioner is trained in gynecologic oncology to provide you with answers.

Our cancer center does more than treat your disease, we help you with other support services. Our disease-specific nurse navigator connects you with community resources, emotional support or nutritional education. The team also provides holistic resources, including a chaplain, social worker, therapist or financial counselor.

The best way to stay healthy is to see your healthcare provider regularly for routine screening. Many of the symptoms of cervical cancer can also be caused by other conditions. If you experience any signs and symptoms of cervical cancer, see a healthcare professional right away. Ignoring these symptoms may allow cancer to progress and decrease your chances at successful treatment.

Prognostic Nomogram For Overall Survival

Backward stepwise regression was used to determine the optimal model. The multivariate analysis for OS in the training cohort included significant independent prognostic factors in the nomogram to predict the 3- and 5-year survival rates .

Figure 2 Cervical cancer survival nomogram.

Abbreviations: SCC, squamous cell carcinoma AC, adenocarcinoma.

Risk Factors For Recurrence

We further analyzed the risk factors for cervical cancer recurrence by constructing Cox proportional hazards regression models . We observed that miscarriage, clinical stage, and treatment received remained significant after adjustment for confounders. More specifically, the recurrence risk for subjects with three or more times of miscarriages was increased by 65% compared to those without a history of miscarriages the HR for subjects with clinical stage II was 1.73 and clinical stage III or IV was 2.04 compared to those with stage I subjects received chemotherapy only were 3.62 times more likely to had recurrence compared to those received surgery only . The sensitivity analysis that excluded subjects with recurrence within 3 months after discharge identified similar risk factors . When only including subjects with clinical stage I and II, we found that age greater than 60 years old was associated with a lower risk of recurrence than those with age younger than 40 years old subjects with more than two times of miscarriages and received chemotherapy only had a higher risk of recurrence .

Table 3 Analyzing factors associated with cervical cancer recurrence using Cox regression models.

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Cervical Cancer Survival Rates

  • Localized. This type of cancer has a 92 percent relative survival rate. It means that if cancer is detected while its still confined to your cervix and uterus, you are 92 percent as likely to be alive in 5 years, compared to a person who doesnt have cervical cancer.
  • Regional. This type of cancer has a 58 percent relative survival rate. If cervical cancer has spread to your uterus and nearby lymph nodes, you are 58 percent as likely to be alive in 5 years as someone who doesnt have cervical cancer.
  • Distant. This cancer has a 17 percent relative survival rate. If cervical cancer has spread to parts of your body that arent close to your cervix, you are 17 percent as likely to be alive in 5 years as a person with no cervical cancer.
  • All stages of cervical cancer combined. This cancer has a 66 percent survival rate. If you have cervical cancer, you are 66 percent as likely as someone without cervical cancer to be alive in 5 years time.

These numbers may not be an accurate reflection of your outlook. Many individual factors can influence the progression of cancer and how your body responds to treatment.

Its important to talk with your oncologist and other people on your cancer care team. They can provide you with information and suggestions on what you can do to improve the outcome of your cancer treatment.

What Goes Into A Prognosis

Stage 3 Endometrial Cancer Life Expectancy

When figuring out your prognosis, your doctor will consider all the things that could affect the cancer and its treatment. Your doctor will look at risk estimates about the exact type and stage of the cancer you have. These estimates are based on what results researchers have seen over many years in thousands of people with the same type and stage of cancer.

If your cancer is likely to respond well to treatment, your doctor will say you have a favorable prognosis. This means youre expected to live many years and may even be cured. If your cancer is likely to be hard to control, your prognosis may be less favorable. The cancer may shorten your life. Its important to keep in mind that a prognosis states whats likely or probable. It is not a prediction of what will definitely happen. No doctor can be fully certain about an outcome.

Your prognosis depends on:

  • The type and location of the cancer

  • The stage of the cancer

  • Your overall health

  • Your treatment decisions

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Stages Of Cervical Cancer

1. Stage 1

Stage one cervical cancers is generally divided into Stage 1A and Stage 1B as they are both in the neck of the womb, yet one is slightly larger than the other. Each of these stages are further divided into 2 sub stages as well.

Stage 1A

  • Stage 1A1 cancer is less than 3mm into the tissue and less than 7mm wide.
  • Stage 1A2 is now 3-5 mm into the cervix tissue however it is still less than 7mm wide.

Stage 1B

Stage 1B is still located only in the cervix tissue and has not spread away and it can be seen without a microscope.

  • Stage 1B1 means that the cancer is less than 4cm.
  • Stage 1B2 means that it has grown larger than 4cm in diameter.

2. Stage 2

Once the cancer begins to spread outside of the womb, but not into the muscles and ligaments, it is called stage 2 cervical cancer. This stage is also divided into two parts: stage 2A and stage 2B.

Stage 2A

  • Stage 2A1 the cancer is less than 4 cm.
  • Sstage 2A2 the cancer is more than 4cm.
  • Most of the time can be treated with surgery or chemoradiation.

Stage 2B

  • The cancerous cells have reached the tissues around the cervix.
  • Can be treated with chemoradiation, which increases the survival rates.

3. Stage 3

Again, this stage is divided into two sub-stages: stage 3A and stage 3B.

  • Stage 3B has spread to the pelvic wall or blocks the uterus.

4. Stage 4

This is the most advanced stage of cervical cancer. At this point it has begun to spread into your other organs.

When To Seek Medical Advice

You should contact your GP if you experience:

  • bleeding after sex
  • bleeding outside of your normal periods
  • new bleeding after the menopause

Vaginal bleeding is very common and can have a wide range of causes, so it doesn’t necessarily mean you have cervical cancer. However, unusual vaginal bleeding is a symptom that needs to be investigated by your GP.

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How Is Cervical Cancer Diagnosed

The most important advance in cervical cancer screening is broader use of the Papanicolaou test and high-risk HPV testing. A Pap smear is part of a womanâs regular pelvic exam. Your doctor collects cells from the surface of your cervix, and a technician looks at them under a microscope. If they spot anything unusual, your doctor will take out a bit of cervical tissue in a procedure called a biopsy.

Other tools can find changes in your cervix. They include:

A colposcopy is like a pelvic exam. Your doctor may use it if a Pap smear finds unusual cells. They stain your cervix with a harmless dye or acetic acid so the cells are easier to see. Then, they use a microscope called a colposcope, which magnifies your cervix by eight to 15 times, to look for unusual cells for biopsy. You can usually have this procedure in your gynecologist’s office. You might need another biopsy later if the colposcopy shows signs of invasive cancer.

In the loop electrosurgical excision procedure , your doctor uses an electrified loop of wire to take a sample of tissue from your cervix. You might have this in your gynecologist’s office.

Your doctor can do a conization in the operating room while youâre under anesthesia. They might use a LEEP, a scalpel , or a laser. These are usually outpatient procedures, so you can go home the same day.

LEEP and cold knife conization procedures give your doctor a better look at the types of unusual cells in your cervix and whether theyâve spread.

How Are Precancerous Lesions Treated

Cervical Cancer: Risk Factors, Pathophysiology, Symptoms, Staging, Diagnosis, Treatment & Prevention

If you have a low-grade lesion, you may not need treatment, especially if your doctor took out the area during a biopsy. Get regular checkups to watch for problems later on.

Your doctor might use LEEP conization, cold knife conization, cryosurgery , cauterization , or laser surgery to destroy the precancerous area with little damage to nearby healthy tissue.

In cryocautery, a steel tool thatâs cooled to subzero temperatures freezes cells on the surface of your cervix. They die and fall off, to be replaced by new cells.

Laser ablation uses a laser beam to destroy cells in areas or layers of cervical tissue, leaving healthy cells in their place.

Youâll need a follow-up exam and Pap smear after cryocautery or laser ablation to make sure all the precancerous cells are gone.

You could also have a hysterectomy, in which your doctor removes your uterus. It will keep you from getting cervical cancer. But because it takes out your reproductive organs, you canât become pregnant afterward.

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Stage Three Survival Rate

The general five-year survival rate for stage three cancer depends on the type of cancer with which you are infected 2. For example, according to EMedTV.com, the survival rate for stage three lung cancer is 15.5 percent, whereas the survival rate for stage three colon cancer is around 64 percent 2. These figures represent the average percentage of patients who will be alive five years after the date of their diagnosis.

What Are Stage 2 Cervical Cancer Treatments

Typically, a combination of chemotherapy and radiation therapy is the best choice. Radiation therapy is both EBRT and chemotherapy. If internal radiation therapy occurs too, it typically involves a hospital stay for placement. While chemotherapy supports radiation therapy, it may have benefits on its own.

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How Is Cervical Cancer Treated

Surgery and radiation therapy are the most common treatments for invasive cervical cancer. Others are chemotherapy and biological therapy.

If the cancer is only on the surface of your cervix, your doctor can remove or destroy the cancerous cells with procedures like LEEP or cold knife conization.

If cancerous cells have passed through a layer called the basement membrane, which separates the surface of your cervix from underlying layers, youâll probably need surgery. If the disease has invaded deeper layers of your cervix but hasnât spread to other parts of your body, you might have an operation to take out the tumor.

If itâs spread into your uterus, your doctor will probably recommend a hysterectomy. Talk with them about the pros and cons.

Radiation therapy uses high-energy rays to damage cancer cells and stop their growth. As with surgery, the radiation affects cancer cells only in the treated area.

Your treatments might be external, internal, or both.

External radiation comes from a large machine that aims a beam of radiation at your pelvis. Youâll probably get treatments, which take only a few minutes, 5 days a week for 5 to 6 weeks. Finally, you may have an extra dose of radiation called a “boost.”

Internal radiation comes from a capsule containing radioactive material, which your doctor puts into your cervix. The implant puts cancer-killing rays close to the tumor while sparing most of the healthy tissue around it.

Characteristics Of The Study Population

Stage 3 Endometrial Cancer Life Expectancy

From January 1992 to December 2005, a total of 4374 subjects diagnosed with cervical cancer and completed the initial treatment in the study hospital were identified. After excluding 16 subjects who were lost to follow-up, we included 4358 subjects with a mean age of 46.5 years in the final analyses. The mean follow-up duration was 7.4 years with a range from 5 to 19 years. In this study, 46.6% of subjects were in clinical stage I, 40.8% of subjects were in clinical stage II, and 12.6% of subjects were in clinical stage III and IV . In addition, 3864 subjects had squamous cell carcinoma, 261 subjects had adenocarcinoma, and 68 subjects had other types of cervical cancer. We found that 479 subjects were well-differentiated, 3332 subjects were moderately differentiated, 172 subjects were poorly differentiated/ undifferentiated.

Table 1 Patient characteristics.

A total of 372 subjects had a cancer relapse during the follow-up period. Subjects with recurrence had significantly younger age, lower parity, and a greater number of miscarriages, and they were more likely to have lymph node metastasis and received chemotherapy .

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Prognosis Of Stage Iii Cervical Cancer: A Two

Huihui Zhou1*, Qi Li2, Chunyan Xu1**, Hong Liang1, Yanan Wang1, Yani Duan1, Min Song2, Yaoxian Wang2, Hong Jin2, Tong Wang1

1 Institute of Keshan Disease, Chinese Center for Endemic Disease Control , Harbin Medical University Cancer Hospital , , China

Contributions: Conception and design: H Zhou, Q Li, T Wang Administrative support: T Wang Provision of study materials or patients: Q Li, M Song, Y Wang, H Jin Collection and assembly of data: H Zhou, H Liang, Y Wang, Y Duan Data analysis and interpretation: H Zhou, T Wang Manuscript writing: All authors Final approval of manuscript: All authors.

*Current: Department of Public Health, Jining Medical University, Jining 272029, China.

**Current: College of Animal Science, Tarim University, Hongqiao South Road, Alar 843300, China.

Correspondence to:

Background: Cervical cancer is the second most common female malignancy worldwide, and the prognosis of patients with the locally advanced stage is poor, with a high risk of recurrent. This study aimed to explore the effect factors that influence the overall survival , progression-free survival , and quality of life in patients with stage III cervical cancer.

Methods: A two-way follow-up method was utilized to collect information from patients with stage III cervical cancer. Survival analyses were performed by the Kaplan-Meier method and Cox regression model. Multiple linear regression was used to analyze the factors related to quality of life.

doi: 10.21037/tcr.2020.02.70

Understanding The Stages Of Cervical Cancer

Cervical cancer is one of the most common forms of gynecologic cancers, with 6 in 1,000 women receiving a cervical cancer diagnosis at some point in their lifetime. In 2020, American Cancer Societys estimates there were an estimated 14,000 new cases of invasive cervical cancer diagnosed in the United States.

With regular gynecologic screenings, your doctor may be able to identify cervical cancer earlier. The earlier cervical cancer is diagnosed the greater your chances for recovering from the disease.

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Tests Used To Determine The Stages

Cervical cancer cells spread either through the lymphatic drainage, blood vessels, or direct proliferation into neighboring tissues. The more they spread, the further they take you down the stages. Your situation gets more precarious with increasing stage numbers.

Certain tests are done to determine the stage of the disease. They include:

  • Cystoscopy. Finds out if it has reached the urinary system.
  • Laparoscopy. The use of an instrument called a laparoscope to check for the disease via an incision.
  • Ultrasound. Uses sound waves to create images of internal organs on a screen.
  • Xrays. Checks the spread to the lungs

Source: Canadian cancer society.

H2 Treatment Of Stage 3 Cervical Cancer

What is the survival rate of Cervical Cancer? – Dr Rajendra Motilal Saraogi

Couple of factors is the major decider on the type of treatment that best suits you. These include the stage of cancer, type of cells involved, location of cancer, and any existing health conditions you may have.

Chemoradiation has been recognized as the standard treatment for stage 3 cervical cancer.Lancelet visit source. This involves the combination of radiation therapy and chemotherapy.

External beam irradiation is given once daily, 5 times weekly for about 5 weeks. During the treatment, chemotherapy is given once weekly or after every 2 to 3 weeks. Your treatment course is then rounded off with internal beam radiation, called Brachytherapy.CancerresearchUK. visit source

For once-weekly chemotherapy, Cisplatin may be the drug of choice for you, and for once every 3 weeks chemo, cisplatin plus 5-fluorouracil may be administered.

3-dimensional conformal radiation therapy has been described which delivers targeted radiation specifically to the tumors in a way that spares surrounding tissues and organs from getting damaged by radiation.American cancer society. visit sourceStudies have shown surgery to be a viable option.

There may still be a need for radiotherapy post-surgery to destroy any remaining cancer cells that may have been missed.American cancer society. visit sourceEuropean Journal of Cancer. visit source

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Stage 3 Cancer Life Expectancy

Understanding the odds of survival is a good starting point for treating cancer, because once you understand the odds you can resolve to beat them 2. Cancer progression is divided into stages, with later stages being more difficult to treat and cure. Stage three cancer is one step away from the final stage and has a lower survival rate and shorter overall life expectancy than stage two 2.

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